Prediction of radiation induced lung damage based on dose distribution and tumour location. A pilot study.

Prediction of radiation induced lung damage based on dose distribution and tumour location. A pilot study. - RT2009-06

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33481

Enrollment

Registered

2009-12-15

Start date

2009-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung cancer (both NSCLC and SCLC)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: . Age > 18 years . WHO PS 0-2 . Stage IIIA/IIIB Non Small Cell Lung Cancer (NSCLC). Planned for conventionally fractionated radiotherapy with or without concomitant chemotherapy, 51-60 Gy. . Limited disease Small Cell Lung Cancer, i.e. tumor confined to hemithorax without evidence of distant metastases or malignant pleural effusion. Planned for conventionally fractionated (chemo)radiotherapy, 45 Gy. . Adequate pulmonary function . Life expectancy of at least 6 months .. Before patient registration, informed consent must be given

Exclusion criteria

Exclusion criteria: . WHO PS=3 . Life expectancy less than 6 months

Design outcomes

Secondary

Measure	Time frame
. The regional dependency of structural lung damage (tumor location) . The relationship between lung density changes and dose distribution . The dynamics of structural lung damage (density changes) in time	—

Primary

Measure	Time frame
Density changes measured with serial CT-scans scored using the newly developed quantification method.	—

Countries

Netherlands

Outcome results