Perioperative techniques for low grade glioma patients: validation of Diffusion Tensor Imaging tractography with subcortical stimulation and prediction of postoperative functional outcome with Resting State Functional Connectivity

Perioperative techniques for low grade glioma patients: validation of Diffusion Tensor Imaging tractography with subcortical stimulation and prediction of postoperative functional outcome with Resting State Functional Connectivity - fMRI and DTI for low grade glioma surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33478

Enrollment

Registered

2009-10-23

Start date

2009-10-23

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

low grade gliomas

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: A) Inclusion criteria Patients with LGG:;1. Candidate for surgical removal of the brain lesion 2. Brain tumour in/near motor or language cortex;B)Inclusion criteria for healthy volunteers:;1. 25-70 years 2. Ability to perform the fMRI tasks

Exclusion criteria

Exclusion criteria: A) Exclusion criteria Patients with LGG:;1. MRI-incompatible metal objects in or around the body (braces, pacemaker, metal fragments, surgical clips) 2. Significant cognitive deficits; non ability to perform the fMRI tasks 3. History of neurological or psychiatric illness, not related to the brain lesion ;B) Exclusion criteria Healthy volunteers:;1. Metal objects in or around the body (braces, pacemaker, metal fragments, surgical clips) 2. History of neurological or psychiatric illness 3. Cerebral abnormalities on screening MRI 4. Pregnancy as determined with a urine pregnancy test before functional MRI scanning (standard procedure for healthy volunteers at the UMC Utrecht)

Design outcomes

Primary

Measure	Time frame
The study aims at detection of critical brain areas for hand motor and language functions, that are normally located on the primary sensorimotor cortex (PSMC), supplementary motor cortex (SMC), Broca and Wernicke`s areas. Damage to either the PSMC, SMC, Broca and Wernicke*s areas can lead to (temporary) loss of motor and language functions, so all areas need to be identified by means of fMRI for optimal surgical planning. Subsequently, FT will be performed based on the DTI scan, and the corticospinal tract (CST, serving motor function), and the superior longitudinal fasciculus tract (SLF, serving language function) will be reconstructed. Then DTI-FT will be correlated with ioESM. RSFC analysis will be performed pre- and postoperatively to study the correlation between RSFC analysis, resected brain area and the functional outcome status of patients, as measured by neuropsychological, psychomotor and language tests.	—

Measure

Time frame

The study aims at detection of critical brain areas for hand motor and language functions, that are normally located on the primary sensorimotor cortex (PSMC), supplementary motor cortex (SMC), Broca and Wernicke`s areas. Damage to either the PSMC, SMC, Broca and Wernicke*s areas can lead to (temporary) loss of motor and language functions, so all areas need to be identified by means of fMRI for optimal surgical planning. Subsequently, FT will be performed based on the DTI scan, and the corticospinal tract (CST, serving motor function), and the superior longitudinal fasciculus tract (SLF, serving language function) will be reconstructed. Then DTI-FT will be correlated with ioESM. RSFC analysis will be performed pre- and postoperatively to study the correlation between RSFC analysis, resected brain area and the functional outcome status of patients, as measured by neuropsychological, psychomotor and language tests.

—

Secondary

Measure	Time frame
Nvt	—

Countries

Netherlands

Outcome results