QUANTIFICATION OF CHOLESTEROL FLUXES IN HUMANS: Assessment of hepatic cholesterol excretion, intestinal absorption and excretion and faecal sterol loss using quadruple stable isotope technique (STORC EXTRA)

QUANTIFICATION OF CHOLESTEROL FLUXES IN HUMANS: Assessment of hepatic cholesterol excretion, intestinal absorption and excretion and faecal sterol loss using quadruple stable isotope technique (STORC EXTRA) - STORC EXTRA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33472

Enrollment

Registered

2009-11-17

Start date

2009-06-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mild hypercholesterolemia slightly elevated cholesterol

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy male subjects, aged 18-65 years, with an LDL-cholesterol concentration between 3.0 and 5.0 mmol/l.

Exclusion criteria

Exclusion criteria: Excluded are persons with genetic hyperlipoproteinemia like familial hypercholesterolemia, LPL-deficiency, familial dysbeta lipoproteinemia and familial hypertriglyceridemia. Also people with diabetes mellitus, severe hypertriglyceridemia, uncontrolled hypertension or history of arterial disease including unstable angina, myocardial infarction, recent transient ischaemic attacks or a cerebro-vascular accident or subjects who use prescribed medication will be excluded.

Design outcomes

Primary

Measure	Time frame
To estimate reference values for reverse cholesterol transport, cholesterol absorption, hepatic cholesterol excretion and direct trans-intestinal cholesterol excretion in humans.	—

Countries

Netherlands

Outcome results