disturbances during the postprandial state metabolic disturbances after a meal
Conditions
Interventions
All subjects will receive four meals in a random order, a meal rich in palm
olein, interesterified palm olein, lard, or high-oleic acid sunflower oil
(control).
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Body mass index (BMI) between 20-35 kg/m2 Age: 18-45 years Serum total cholesterol
Exclusion criteria
Exclusion criteria: -Smoking -(Drug treatment against) Diabetes Mellitus -Cardiovascular disease -Familial hypercholesterolemia or lipid-lowering medication -Diseases that can interfre with the outcome of the studies such as: COPD, asthma, epilepsy, IBD, reumatoid arthritis -Unstable body weight (>3 kg weight gain or weight loss during the past 3 months) -Abuse of drugs or alcohol (>28 consumptions a week) -Participation in another trial or use of experimental products during the last months -Having donated blood during the last two months -Difficult or impossible to puncture during screening -Not willing to consume animal-derived products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolic risk markers related to cardiovascular disease: Primary endpoints are postprandial lipemia and glycemia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are changes in postprandial concentrations of insulin, and factors related to low-grade systemic inflammation and clotting activity, and of gut hormones. | — |
Countries
Netherlands
Outcome results
None listed