Lack of Empathy as a Symptom in various Psychiatric Disorders

Lack of Empathy as a Symptom in various Psychiatric Disorders - Psychopathology and the Lack of Empathy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33461

Enrollment

130

Registered

2009-04-27

Start date

2010-03-31

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

autisme Conduct Disorder

Interventions

Part 2 of this study: every participant will be assigned at random to a group in which oxytocin will be administered once-only or a group in which placebo will be administered. After this test perfo

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: Boys, aged 12 to 19 years, with an average intelligence (Total IQ >= 80; according to DSM-IV-TR), and with a diagnosis of Autism of Conduct Disorder. Subjects need to meet criteria according to the DISC-IV computer version. This is a structured questionnaire, which has to be filled in by parents, and which aims at psychopathology according to DSM-IV-TR criteria

Exclusion criteria

Exclusion criteria: Youth using medication which can influence facial expression (i.e., antipsychotics and certain antidepressants) and temporary discontinuation of medication is contraindicated (i.e., psychotic disorder, severe major depression) will be excluded. Whether discontinuation is appropriate will be decided by mutual agreement with the subject, the psychiatrist treating the subject, and if necessary, parents of the subject. If so, discontinuation will last for at least 5 times half-life of the medication used, and will be continued the day after participation in the investigation. Furthermore, youth with prominent comorbidity which could influence neurologic or neurocognitive functioning, such as: • schizofrenia, psychotic disorder • bipolar disorder • substance abuse of dependency • tics • language disorder • epilepsy.

Design outcomes

Primary

Measure	Time frame
Facial EMG Hart rate and skin conductance Hormone levels (cortisol, testosterone, oxytocin in saliva) Results on neurocognitive tests, focusing on empathy, Theory of Mind, facial recognition	—

Secondary

Measure	Time frame
Psychopathic traits Perception, attention and concentration Executive functioning Mood and anxiety Self-report on empathy Eye-movement (eye-tracker)	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)