FDG-PET CT scan: an additional tool in detection of peripheral arterial disease and its compensatory capacities in patients with diabetes type 2, an observational pilot study.

FDG-PET CT scan: an additional tool in detection of peripheral arterial disease and its compensatory capacities in patients with diabetes type 2, an observational pilot study. - FDG-PET scan in peripheral arterial disease in diabetes type 2

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33453

Enrollment

Registered

2009-03-23

Start date

2009-03-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atheroslerosis peripheral arterial disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: type 2 diabetes, presence of an threatened distal circulation no smoking.

Exclusion criteria

Exclusion criteria: pregnancy or an actual wish for pregnancy lactation period less than a year in the postmenopausal state HbA1c > 11% at random glucose level more than 12 mmol/l at time of FGDPET scan.

Design outcomes

Primary

Measure	Time frame
1. Assessment of FDG uptake by PET imaging along plaques in the distal vasculature of the lower limbs that is compared with presence of atherosclerotic lesions within the same individual (as determined by conventional CT scanning). 2. Difference in the distribution of FDG uptake by endothelium (at baseline vs. after temporary occlusion by use of a tourniquet for 3 minutes) for each predefined segment along the distal vasculature.	—

Measure

Time frame

1. Assessment of FDG uptake by PET imaging along plaques in the distal vasculature of the lower limbs that is compared with presence of atherosclerotic lesions within the same individual (as determined by conventional CT scanning). 2. Difference in the distribution of FDG uptake by endothelium (at baseline vs. after temporary occlusion by use of a tourniquet for 3 minutes) for each predefined segment along the distal vasculature.

—

Secondary

Measure	Time frame
1. To evaluate whether FDG uptake significantly correlates to vascular plaques on CT 2. To evaluate whether a FDG PET-derived ischemic border zone correlate with conventional clinical scores of ischemia	—

Countries

Netherlands

Outcome results