Anorexia Nervosa Anorexia.
Conditions
Interventions
MRI during the presentation of food images.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Right-handed - Chronically ill AN patients should have suffered from the illness for at least two years (as defined by the DSM IV criteria) and have a BMI below 17.5 kg/m2. - The women recovered from AN should be weight-recovered for at least 1 year (BMI > 17.5 kg/m2) and have a regular menstrual cycle - Healthy control women should have a normal BMI, i.e. between 18.5 and 25 kg/m2 and a regular menstrual cycle.
Exclusion criteria
Exclusion criteria: - Contra-indications to MRI scanning on the basis of the MRI screening form, including: Claustrophobia, pregnancy, metal objects in the body incompatible with MRI scanning. - Having a history of or current excessive alcohol consumption (> 28 units per week) - Having a drug dependency - Smoking daily - Having a history of medical or surgical events that may significantly affect the study outcome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) The brain activation associated with viewing food stimuli. 2) Serum concentrations of leptin, ghrelin and PYY. 3) Measures of cognitive functioning, in particular the Wisconsin Card Sorting Test (set shifting ability), and the Iowa Gambling Task (decision making performance). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Subjective ratings of the desire to eat, 2) Subjective ratings of anxiety, 3) Energy intake (kJ) from the test meal. | — |
Countries
Netherlands
Outcome results
None listed