hospital bacteria MRSA
Conditions
Interventions
None listed
Sponsors
Sint Elisabeth Ziekenhuis
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Individuals of any age are eligible and should be: 1 - Working with pigs or veal calves on a farm (primary exposed) or 2 - Living on a pig or veal farm and not working with the animals (secondary exposed)
Exclusion criteria
Exclusion criteria: - Treatment for colonization of MRSA in the last 3 months of any potential participant (farm will be excluded) - Being colonized with other types of MRSA than CC398
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the prevalence of persistent MRSA carriage in primary versus secondary exposed persons. A secondary case is defined as a household member that carries MRSA-CC398 on a farm were MRSA was found during the study period. Persistent carriage is defined as all samplings being positive for MRSA, intermittent carriage is defined as 1 to 5 out of 6 samples positive. If none of the samples return MRSA it is referred to as non-carriage. Adjustment for factors that may influence persistent carriage, e.g. carriage of methicillin susceptible S. aureus (MSSA), throat carriage, the amount of MRSA present in the nose or throat and the presence of MRSA in wounds or skin diseases will be done. Furthermore, the association between the number of positive samples during the initial 3 swabs and the carriage status at 4, 8 and 12 months is determined. This is done for both MSSA and MRSA. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the amount of disease associated with carriage of MRSA-CC398 the occurrence of medical events will be recorded. Not only infections caused by MRSA are included in this follow-up but also visits to the general practitionar, use of antibiotics, hospital admissions etc. Adjustment for factors that may affect the occurrence of disease will be done using regression analysis. Lastly the exposure to dust on MRSA positive farms will be studied, using information from questionnaires, personal dust samplers and environmental samples from house and stable. | — |
Countries
Netherlands
Outcome results
None listed