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Validation of a Prognostic Profile of Non Small Cell Lung Cancer in biopsies, PulmoPrint

Validation of a Prognostic Profile of Non Small Cell Lung Cancer in biopsies, PulmoPrint - PulmoPrint in bronchial biopsies

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON33429
Enrollment
15
Registered
2010-01-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer Non-small cell lung carcinoma

Interventions

None listed

Sponsors

Antoni van Leeuwenhoek Ziekenhuis
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Patients with stage I or II of NSCLC who will undergo a resection 2. All histological subtypes of NSCLC 3. signed Informed consent

Exclusion criteria

Exclusion criteria: 1. Prior radiotherapy to target tumor 2. neo adjuvant treatment

Design outcomes

Primary

MeasureTime frame
Can the prognosis profile (or other genomic profiles) be performed on biopsy material (feasibility) and is the gene expression in the biopsy sample comparable to the expression in the surgical specimen?—

Secondary

MeasureTime frame
- What percentage of mismatch is due to heterogeneity within the tumor? - What percentage of biopsies has too little (less than 30%) or no cancer cells as assessed by H&E staining? - To what degree correlate the results from biopsy with the results from surgical specimen based on microarray results as well as IHC markers?—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)