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The effects of increased levels of dopamine on the activation in the dopaminergic system.

The effects of increased levels of dopamine on the activation in the dopaminergic system. - The dopaminergic system

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON33408
Enrollment
20
Registered
2009-08-07
Start date
2010-06-07
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

n.v.t.

Interventions

None listed

Sponsors

Universiteit Maastricht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Good health, right-handedness, male, between 23 and 35 years of age, no history of mental illnesses or neurological disorders, no history of drug or alcohol abuse, no use of medication.

Exclusion criteria

Exclusion criteria: MRI contra-indications, such as claustrophobia and metal parts in the body, cardiovascular abnormalities as assessed by standard 12-lead electrocardiogram (ECG), excessive drinking and hypertension.

Design outcomes

Primary

MeasureTime frame
1) Regional cerebral blood flow (method: arterial spin labeling MRI) during resting state in the cortex, sub cortical and brain stem regions. 2) Regional blood oxygenated level dependent (BOLD) response (method: BOLD functional MRI) during resting state and during task performance, in the cortex, sub cortical and brain stem regions. 3) Task performance; the number of correct response and the reaction time.

Secondary

MeasureTime frame
1) The levels of Ritalinic acid in the blood 2) Mood and physical complaints (method: questionnaire) 3) Hart and breathing rate (assessed during the scan session)

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)