Diagnostic role of upper endoscopy in differentiating ulcerative colitis from Crohns disease in adults*

*Diagnostic role of upper endoscopy in differentiating ulcerative colitis from Crohn*s disease in adults* - 'Upper endoscopy in Inflammatory Bowel Disease'

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33405

Enrollment

233

Registered

2009-09-14

Start date

2010-02-08

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's disease inflammatory bowel disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients clinically suspected of IBD (chronic diarrhoea, abdominal pain) and endoscopic lesions suggestive for IBD. All patients must be >18 years old and give informed consent.

Exclusion criteria

Exclusion criteria: Patients with a history of stomach resection, Helicobacter pylori treatment in the last six months, and patients in whom discontinuation of NSAID*s or proton pomp inhibitor (PPI*s) is absolutely contraindicated.

Design outcomes

Primary

Measure	Time frame
1. The difference between the prevalence of 'focal enhanced gastritis'in gastric biopsies of patients with Crohn*s disease (CD) and ulcerative colitis (UC). 2. The difference in the T-cel subpopulations and their proinflammatory cytokine profile in blood and the inflamed gastric and intestinal mucosa between patients with different IBD phenotyes (CD, UC and IBD unclassified).	—

Secondary

Measure	Time frame
1. Description of specific histological lesions, other than focal enhanced gastritis in gastric mucosa of patients with different IBD phenotype.	—

Countries

Netherlands

Outcome results