Sarcopenia
Conditions
Interventions
The proposed intervention is a 6 month randomized control trial, with 4 arms in
parallel (2x2 factorial design). In this study, the effect of a daily protein
supplementation (2x 15g provided at brea
Sponsors
TIFN
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Elderly people: > 65 years • frail elderly individuals (based on MNA, CES-D Depression Scale and physical inactivity) • Male and female • Able to understand and perform the study procedures
Exclusion criteria
Exclusion criteria: •• Type I or type II diabetes (fasted blood glucose level >=7,0) • No recent history (within 2 years) of participating in any regular resistance exercise training program (general questionnaire) • Use of anti-coagulation medication (except of Acetyl Salicyl acid) • Presence of coronary heart disease (ECG) • Renal insufficiency (creatinine level > 200 mmol/l) • High blood pressure (>160 mm Hg systolic) • Allergic or sensitive for milk proteins
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure of this study will be change in skeletal muscle mass after the 6 month intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical function Musclefibre hypertrophy Intracellulair protein synthesis pathways Nitrogen balance 3-methylhistidine Nutritional intake Physical Activity measurement Cognitive functioning Depression Bloodpressure | — |
Countries
Netherlands
Outcome results
None listed