Sarcoidosis and Fatigue: Influence of successive cardiopulmonary exercise testing on fatigue, ACE, cytokine response and acitivity pattern

Sarcoidosis and Fatigue: Influence of successive cardiopulmonary exercise testing on fatigue, ACE, cytokine response and acitivity pattern - Sarcoidosis and fatigue

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33379

Enrollment

Registered

2009-09-08

Start date

2010-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morbus Besnier Boeck (Schaumann) Sarcoidosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Sarcoidosis diagnosis confirmed within 1 year before inclusion 18 years and older informed consent see protocol section 4.2

Exclusion criteria

Exclusion criteria: corticosteroid use, cardiovasculair comorbidity see protocol section 4.3

Design outcomes

Primary

Measure	Time frame
Recuperative capacity: Outcome on two maximal exercise tests (bicycle ergometer): comparing results of cardiovascular, pulmonary and aerobic capacity on two successive days. Fatigue: State of fatigue (before and after exercise) will be evaluated by Visual Analogue Scales. Trend of fatigue (at the start of taking part in this study and after completing) will be measured with the CIS-20R-08-questionnaire. Measurements in serum: Level of ACE, including genotype of patients for ACE and levels of cytokines will be determined (IL-6 and TNF-a before and after exercise).	—

Measure

Time frame

Recuperative capacity: Outcome on two maximal exercise tests (bicycle ergometer): comparing results of cardiovascular, pulmonary and aerobic capacity on two successive days. Fatigue: State of fatigue (before and after exercise) will be evaluated by Visual Analogue Scales. Trend of fatigue (at the start of taking part in this study and after completing) will be measured with the CIS-20R-08-questionnaire. Measurements in serum: Level of ACE, including genotype of patients for ACE and levels of cytokines will be determined (IL-6 and TNF-a before and after exercise).

—

Secondary

Measure	Time frame
Secondary objective is to find associations between exercise and patterns of sleep behaviour and acitivity, not only on basis of patient reports, but also objectified bij means of an accelerometer.	—

Countries

Netherlands

Outcome results