mild hypercholesterolemia slightly elevated cholesterol
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy male and female subjects, aged 18-65 years old, with an LDL-cholesterol concentration between 3.0 and 5.0 mmol/l, who participated in the Dahlia-1 study and belong to the 40 subjects with the highest or to the 40 subjects with the lowest plasma campesterol/TC ratios respectively.
Exclusion criteria
Exclusion criteria: Excluded are persons with a genetic hyperlipoproteinemia like familial hypercholesterolemia, LPL-deficiency, familial dysbeta lipoproteinemia and familial hypertriglyceridemia. Also people with diabetes mellitus, severe hypertriglyceridemia, uncontrolled hypertension or history of arterial disease including unstable angina, myocardial infarction, recent transient ischaemic attacks or a cerebro-vascular accident, will be excluded.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Correlation of cholesterol absorption as measured by the dual isotope method with cholesterol absorption as measured by the continuous feeding method. | — |
Primary
| Measure | Time frame |
|---|---|
| 1. The difference in fractional cholesterol absorption, determined by the dual isotope method, between 40 subjects with high and 40 subjects with low baseline campesterol/TC ratios (combined results of Dahlia-2 and Dahlia-2a study). 2. Correlation of plasma campesterol/TC ratios with cholesterol absorption, determined by the dual isotope method in 80 subjects with mild hypercholesterolemia (combined results of Dahlia-2 and Dahlia-2a study). | — |
Countries
Netherlands
Outcome results
None listed