type 2 diabetes mellitus
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age between 65 and 80 years diabetes patients: diagnosed with diabetes for more than 1 year
Exclusion criteria
Exclusion criteria: - Dementia - TIA or non-invalidating stroke in the past 2 years or any invalidating stroke. - Other neurological diseases, unrelated to DM2, that are likely to affect cognition, including a history of brain trauma requiring hospitalisation - Known with or history of psychiatric disorders requiring hospitalisation or >12 months medication use (e.g. schizophrenia , Major depression (DSM IV)) - Contra-indication for 7 Tesla MR imaging (as established by the department)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The prevalence and total number of microinfarcts and microbleeds at 7T in relation to DM2 status and cognition. | — |
Secondary
| Measure | Time frame |
|---|---|
| Microvascular lesion load will be related to cognition, conventional MR markers (atrophy, white matter hyperintensities), vascular and metabolic risk factors, brain connectivity parameters and cerebral blood flow. | — |
Countries
Netherlands
Outcome results
None listed