Prokinetics to alter the position of the gastric acid pocket in Gastro Esophageal Reflux Disease

Prokinetics to alter the position of the gastric acid pocket in Gastro Esophageal Reflux Disease - prokinetics and the acid pocket

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON33309

Enrollment

Registered

2009-11-23

Start date

2009-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux disease heartburn

Interventions

administration of azitromycin

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: GERD patients with a hiatal hernia - 18-65 years - esophagitis and/or pH-metry with an acid exposure of > 4,5% - hiatal hernia as seen on endoscopy or barium swallow of > 3 cm GERD patients without a hiatal hernia - 18-65 years - esophagitis and/or pH-metry with an acid exposure of > 4,5% - no hiatal hernia or a hiatal hernia

Exclusion criteria

Exclusion criteria: Exclusion criteria - surgery of the gastrointestinal tract other then appendectomy - use of medication that interfere with gastrointestinal motility - inability to stop the use of proton pump inhibitors for one week

Design outcomes

Secondary

Measure	Time frame
- The number of TLESRs - Proximal extent of reflux episodes - The rate of gastric emptying	—

Primary

Measure	Time frame
- The number of reflux episodes. Acid, non acid and alkaline. - The distance of the acid pocket to the crural diaphragm and LES	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)