Subthalamic nucleus in cognitive control and inhibition

Subthalamic nucleus in cognitive control and inhibition - Subthalamic cognition and inhibition

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33300

Enrollment

Registered

2009-11-20

Start date

2009-04-20

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with parkinson's disease bilateral STN deep brain stimulation

Exclusion criteria

Exclusion criteria: below normal intelligence severe motoric disturbances

Design outcomes

Primary

Measure	Time frame
Mechanisms of cognitive control and inhibition a. simple RT-task, a single stimulus is presented and the subject has to respond by pressing a button as soon as possible b. choice RT-task, a light on the left or the right side of the monitor shows up and the the subject has to press a button as soon as possible ipsilateral to the stimulus presented c. GO/NOGO task, after a warning stimulus a GO-stimulus (e.g. green light, press the button) is presented or a NOGO stimulus (e.g. red light, do not press the button) d. STOP-task, similar to the preceding GO/NOGO task, but some of the GO stimuli (e.g. green light) will directly be followed by an overrulling STOP stimulus (e.g. red light) Perception of emotional expression and body-language Patients are placed within a Faraday cage in front of a monitor. The monitor shows simultaniously faces with various expressions. The patient has to decide and subsequently indicate with a button press which faces are showing a similar expression. In a comparable task, instead of faces pictures of bodies are used. Subjects have to decide which bodies have a similar emotion value. Motoric and sensoric timing In a tapping task, where a number of clicks are presented in a fixed rhythm, the patient is asked to tap according to the auditory stimuli and after discontinuation of the auditory stimuli, he or she has to continue tapping in the rhythm. Next a discrimination task will be excecuted. Two small light are presented with variabel intervals. The first light will flash 500ms, 1000ms, or 1500ms. The second may shorter, identical, or longer and the subject has to decide which is the case.	—

Measure

Time frame

Mechanisms of cognitive control and inhibition a. simple RT-task, a single stimulus is presented and the subject has to respond by pressing a button as soon as possible b. choice RT-task, a light on the left or the right side of the monitor shows up and the the subject has to press a button as soon as possible ipsilateral to the stimulus presented c. GO/NOGO task, after a warning stimulus a GO-stimulus (e.g. green light, press the button) is presented or a NOGO stimulus (e.g. red light, do not press the button) d. STOP-task, similar to the preceding GO/NOGO task, but some of the GO stimuli (e.g. green light) will directly be followed by an overrulling STOP stimulus (e.g. red light) Perception of emotional expression and body-language Patients are placed within a Faraday cage in front of a monitor. The monitor shows simultaniously faces with various expressions. The patient has to decide and subsequently indicate with a button press which faces are showing a similar expression. In a comparable task, instead of faces pictures of bodies are used. Subjects have to decide which bodies have a similar emotion value. Motoric and sensoric timing In a tapping task, where a number of clicks are presented in a fixed rhythm, the patient is asked to tap according to the auditory stimuli and after discontinuation of the auditory stimuli, he or she has to continue tapping in the rhythm. Next a discrimination task will be excecuted. Two small light are presented with variabel intervals. The first light will flash 500ms, 1000ms, or 1500ms. The second may shorter, identical, or longer and the subject has to decide which is the case.

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Countries

Netherlands

Outcome results