niet van toepassing nvt
Conditions
Interventions
We will use 40-second continuous theta-burst stimulation (cTBS). cTBS refers to
a simulation paradigm in which participants receive brief trains of pulses of
50 Hz in a 5 Hz (the theta frequency) rh
Classen & Stefan 2007), but recent studies showed an
effect of cTBS on V1 (Franca et al., 2006), PPC, and vertex (Hilgetag et al.
2001
Nyffeler et al., 2008). Thus, cTBS has already been tested and found safe
as a method of stimulating all the regions that we will target in the present
study.
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Right-handed individuals, with normal or corrected-to-normal vision and no history of neurological or psychological disorders are included.
Exclusion criteria
Exclusion criteria: - Pacemaker - Metal parts in head or mouth - History of brain surgery - History of epilepsy or first-grade family member with epilepsy - Psychological or neurological disorder - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of TMS on the three stimulation sites in the main experiment will be assessed using a visual task performed in an fMRI scanner. We will test whether stimulation to V1, PPC, and vertex differentially affected subjects* visibility ratings. We predict that V1 stimulation will lead to decrease in visibility ratings for gratings presented anywhere in the visual field, while PPC stimulation will only affect the visibility of gratings in the contralateral visual field. Vertex stimulation is not expected to have any effects on visibility ratings. Further, we predict that the changes in visibility rating will be mediated by changes in the activation patterns in the prefrontal cortex and will test for that in the fMRI part of the experiment. | — |
Secondary
| Measure | Time frame |
|---|---|
| The effectiveness of TMS stimulation will be assessed in a pilot experiment. We will test whether stimulation to V1, PPC, and vertex differentially affected subjects* visibility ratings. Again, we predict that V1 stimulation will lead to decrease in visibility ratings for gratings presented anywhere in the visual field, while PPC stimulation will only affect the visibility of gratings in the contralateral visual field. Vertex stimulation is not expected to have any effects on visibility ratings. In the pilot experiment we will only collect behavioural data in order to assess the effectiveness of TMS. | — |
Countries
Netherlands
Outcome results
None listed