diepte van anesthesie tijdens operatie optimize anesthesia
Conditions
Interventions
pseudo-steady-state concentrations of remifentanil and various steady state
level of BIS as guided by propofol effect compartment controlled TCI
(closed-loop). protocol blz.8
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All patients: Age > 18 years and
Exclusion criteria
Exclusion criteria: patient refusal weight less than 70% or more than 130% of ideal body weight, neurological disorder recent use of psycho-active medication, including alcohol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of the BIS and CVI after a standard pain stimulus during various steady-state effect-site BIS levels and remifentanil as calculated by the software program Rugloop II (Demed Engineering, Temse, Belgium). Continuous bilateral BIS values throughout the study period. | — |
Secondary
| Measure | Time frame |
|---|---|
| to compare the changes in other vital signs such as heart rate and blood pressure compared to CVI in response to a standardized noxious stimulus during various targeted pseudo-steady-state concentrations of remifentanil and various steady state level of BIS as guided by propofol effect compartment controlled TCI (closed-loop). | — |
Countries
Netherlands
Outcome results
None listed