functioneren onder hypoxie hypoxia insufficient oxygen
Conditions
Interventions
Partly deoxygenated air will be inhaled by the subjects with a special
breathing mask. Oxygen saturation levels will be manipulated and actively kept
constant at (1) 98%, baseline sea level, (2) 90%
Sponsors
TNO
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Non smoking, or stopped at least 1 years ago. 2. Aged between 18 and 30 years, at day 01 of the study. 3. Apparently healthy based on the anamnesis (see appendix). 4. Having given their written informed consent. 5. Wiling to comply with the study procedures. 6. Willing to accept use of all anonymous data, including publication, and the confidential use and storage of all data. 7. Willing to accept the disclosure of the financial benefit of participation in the study to the authorities concerned.
Exclusion criteria
Exclusion criteria: 1.Medical problems (amongst others, cardiovascular and respiratory diseases). 2.No use of prescribed medication in the last 14 days prior to start of the study, with the exception of the use of aspirins and ibuprofen and oral contraceptives (o.a.c.). These can be taken until 72 hours prior to the start (this does not apply for o.a.c.) . 3.Use of drugs. 4.Sickness in the last 7 days prior to the start of the study. 5.Not willing to except the transfer of relevant study results to their physician. 6.Having donated blood in the last 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are cognitive functioning (working memory, tracking, vigilance, planning), blood oxygen saturation levels (cerebral), brain activity of the frontal cortex, heart rate and blood pressure. | — |
Secondary
| Measure | Time frame |
|---|---|
| peripheral oxygen saturation levels, heart rate and blood pressure. | — |
Countries
Netherlands
Outcome results
None listed