Influence of factor VIII concentrate infusion on platelet activation, inflammatory parameters and endothelial parameters; a pilot study

Influence of factor VIII concentrate infusion on platelet activation, inflammatory parameters and endothelial parameters; a pilot study - Influence of factor VIII concentrate infusion

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33269

Enrollment

Registered

2009-04-21

Start date

2009-07-02

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bleeding disorder Hemophilia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Severe hemophilia A 18 years and older Scheduled for an elective operation

Exclusion criteria

Exclusion criteria: Hemophilia patients with symptomatic cardiovascular disease Hemophilia patients with HIV and/or HCV

Design outcomes

Primary

Measure	Time frame
Inflammatory and endothelial parameters - Inflammation: hs-CRP, IL-1, -6, -8, TNFa - Endothelial activation : sVCAM-1, sICAM-1, MCP-1 Platelet activity and responsiveness - Platelet activity markers - Platelet responsiveness to ADP and XL-CRP stimulation, and to Iloprost and SNAP inhibition	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results