COPD
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age between 40 and 75 years A medical indication to undergo a bronchoscopy;Inclusion criteria for healthy smokers: • Individuals who currently smoke >= 10 cigarettes/day and > 10 packyears. • Documented FEV1 > 80% predicted, FEV1/FVC > 70%.;Inclusion criteria for healthy never smokers: •Individuals, who have not smoked during the at least last year, have never smoked for as long as a year (i.e. at least one cigarette per day or one cigar per week, AND have 80% predicted, FEV1/FVC > 70%.;Inclusion criteria for healthy ex-smokers: • Individuals, who have not smoked during the last year, but who do have a smoking history with at least 10 packyears. •Documented FEV1 > 80% predicted, FEV1/FVC > 70%.;inclusion criteria for smokers with COPD: • > 10 packyears and current smoking. • FEV1 10 packyears. No smoking during the last year and a smoking history with at least 10 packyears. • FEV1
Exclusion criteria
Exclusion criteria: Use of an anticoagulans (i.e. vitamin K antagonists) or the use of LMWh (low molecular weight heparin).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in the production of IL-8 in human bronchial epithelial cells after treatment with an ADAM inhibitor. Difference between patients with COPD and healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| •The production of inflammatory mediators (TGF-a, IL-8, MUC5AC) before and after stimulation (with cigarette smoke or PMA). Differences between patients with COPD and healthy controls (never-smokers, ex-smokers, and current smokers). •Decrease in the PMA- or smoke-induced production of inflammatory mediators after treatment with a selective or nonselective ADAM inhibitor. Differences between COPD and healthy controls (never-smokers, ex-smokers, and current smokers). | — |
Countries
Netherlands
Outcome results
None listed