Diabetes Glucose Metabolism Disorders
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Type 1 diabetes mellitus or healthy control Infomed consent Age > 18 and
Exclusion criteria
Exclusion criteria: Peripheral vascular disease or findings suggestive of peripheral vascular disease on examination (reduced or unobtainable pulses in the feet) Pain caused by diabetic polyneuropathy Psychiatric disorder and/or use of antipsychotic or antidepressant drugs Working on night shifts (last 3 months) Pregnancy comorbidity that influence microvascular or thermoregulatory function Hypertension (>140/90 mmHg) Use of medication known to affect glucose metabolism (e.g. prednison) Chronic use of sleep medication and/or melatonin Medication that influences temperature regulation (e.g. paracetamol, aspirin) Presence of a medical disorder (other than DM) known to be associated with neuropathy Caffeine-, Nicotine-, Alcohol- abuse Use of soft-, harddrugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucose levels (only DM1) by subcutaneous, continuous glucosesensor (Only in diabetic patients) Body temperature recordings: - Registration of distal and proximal skin temperature by iButton - Core body temperature measured by JONAH-capsule Sleep-wake cycle by Actigraphy Subjective sleep and daytime sleepiness by sleep questionnaires and SART Quantitative Sensory testing by the modified Toronto clinical neuropathy score (mTCNs) and the Thermal Sensory Analyzer (TSA) Objective sleep characteristics by Polysomnography (PSG) | — |
Secondary
| Measure | Time frame |
|---|---|
| None | — |
Countries
Netherlands
Outcome results
None listed