liver fibrosis scarring of liver parenchyma
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients over 18 years of age; Patients suspected of chronic viral or chronic non-alcoholic liver disease with an indication for liver biopsy (ASAT elevated >60 mmol/l (n
Exclusion criteria
Exclusion criteria: Patients under 18 years of age; Alcohol consumption of >3 units/day for males and >2 units/day for females; Patients who are pregnant; Patients who are claustrophobic (MRI scanner); Patients who have magnetic or radiofrequency sensitive implants (MRI scanner); Patients with extreme obesity (MRI scanner)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of the diagnostic accuracy of MR Elastography in diagnosing liver fibrosis compared with FibroScan and histopathology in patients suspected of chronic viral liver disease and non-alcoholic fatty liver disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| *The feasibility of combining MR Elastography and proton MR Spectroscopy in non-alcoholic fatty liver disease to distinguish between simple steatosis and NASH. *The evaluation of antiviral treatment response with combined MR Elastography and MR Spectroscopy versus FibroScan in patients with chronic viral liver disease. *The influence of increased hepatic fat content and inflammatory activity on viscoelasticity measurements. *The burden of liver biopsy, MR Elastography and FibroScan. | — |
Countries
Netherlands
Outcome results
None listed