increased permeabiliy leaky gut syndrome
Conditions
Interventions
During this study, alcohol will be administered intraduodenally to induce
changes in the intestinal permeability. The exact dose of ethanol will be
determined in the pilot study
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Signed informed consent - Male gender - Age between 18 and 45 years - Normal medical history and physical examination - Normal liver function tests - Caucausian ethnicity - BMI between 18 and 30
Exclusion criteria
Exclusion criteria: - History of gastrointestinal disorders or abdominal surgery (uncomplicated appendectomy and cholecystectomy allowed, other surgery upon judgement of the principal investigator) - History of alcohol abuse or current excessive alcolhol consumption (>2 alcoholic beverages per day or >14 alcoholic beverages per week) - Recent or chronic medications that may interact with ethanol metabolism or intestinal permeability - Smoking
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes are assessing tight junctions structure in the biopsy specimens, measuring serum and mucosal ethanol and acetaldehyde concentrations. Ex vivo determination of the effect of ethanol and acetaldehyde on tight junction functionality using Ussing chambers | — |
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is to assess the small intestinal permeability by means of sugar permeability testing after intraduodenal administration of ethanol. | — |
Countries
Netherlands
Outcome results
None listed