Effect of familial intrahepatic cholestasis type 1 on the nose potential difference response.

Effect of familial intrahepatic cholestasis type 1 on the nose potential difference response. - FIC1 and NPD-measurement

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33224

Enrollment

Registered

2010-01-04

Start date

2010-01-22

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bile accumulation familial intrahepatic cholestasis type 1 (FIC1 disease)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Diagnosis of ATP8B1-deficiency which means two mutations identified in the ATP8B1-gene and at least one episode of normal or low γ-glutamyl transpeptidase (GGT) cholestasis. Normal value: *

Exclusion criteria

Exclusion criteria: - Age younger than 18 years. - inflammation of the nasal respiratory epithelium, localized hemorrhage or viral infection in the nasal epithelium. - Smokers.

Design outcomes

Primary

Measure	Time frame
Potential difference in milivolt (mV) in the nasal epithelium.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results