Cerebral Perfusion Imaging in Children with Sickle Cell Disease

Cerebral Perfusion Imaging in Children with Sickle Cell Disease - Cerebral Perfusion in Sickle Cell Disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33195

Enrollment

Registered

2009-11-26

Start date

2009-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hereditary anemia Sickle cell disease

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: 35 children with sickle cell disease aged between 8 and 20 years, without history of symptomatic infarction and 15 age-matched controls without SCD

Exclusion criteria

Exclusion criteria: The presence of metal in the body (e.g. osteosynthetic material, pacemaker, artificial cardiac valves); claustrophobia; surgery performed in the area of measurement; known or symptomatic brain infarction; already on chronic blood transfusion schedule.

Design outcomes

Primary

Measure	Time frame
Whole brain and regional CBF measured by ASL at 3T MRI (ml/100g/min). Neurological and neuropsychological findings.	—

Secondary

Measure	Time frame
Regional arrival time of arterial blood as measured by ASL (ms).	—

Countries

Netherlands

Outcome results