Effect of left and right lateral positioning on gastroesophagel reflux (GER) and underlying mechanisms in GER disease patients and healthy controls

Effect of left and right lateral positioning on gastroesophagel reflux (GER) and underlying mechanisms in GER disease patients and healthy controls - Posture and gastro-esophageal reflux in disease and health

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33184

Enrollment

Registered

2009-09-14

Start date

2009-03-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heartburn Reflux

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: GERD * Written informed consent. * >18 yr of age. * 2 of the following criteria: o GERD proved by pH-monitoring with reflux index >5.8% (Richter et al 1992). o Combined pH-MII monitoring with SAP>95% o Reflux esophagitis * grade I as confirmed by endoscopy. * GERD symptoms > 3 months and >2x per week. Healthy controls * Written informed consent. * >18 yr of age. * No GERD symptoms or

Exclusion criteria

Exclusion criteria: Exclusion criteria * Previous gastro-intestinal surgery (with the exception of appendectomy). * Any condition that will make it unsafe the subject to participate. * Congenital abnormalities affecting the gastro-intestinal tract. * Mental retardation. * Hiatus hernia. * Gravida. * Any condition that will make discontinuation of medication impossible, as determined by the treating physician.

Design outcomes

Primary

Measure	Time frame
1) Time to first TLESR 2) Number of TLESRs in the first 15 minutes 3) Total number of TLESRs 4) Cumulative 13C excretion at first TLESR 5) Gastric volume (number of voxels) at first TLESR.	—

Secondary

Measure	Time frame
1) Total number of acid/ weakly acidic/ weakly alkaline GER episodes 2) Total number of liquid/mixed/gas GER 3) Total gastric volume (number of voxels) 4) Total gastric emptying time	—

Countries

Netherlands

Outcome results