diffuse malignant brainstem glioma malignant brain tumour
Conditions
Interventions
Ketogenic diet (first Classical version of the diet with shakes , soups and
smoothies) after that the MCT version of the diet
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: - recurrent or progressive pons glioma - 1-18 years of age - failure of treatment with radiotherapy and Temozolomide and no therapeutic options left - good Dutch reading and writing (parents of caregivers) - Informed Consent of parents/care givers and/or the child (when >12) - willingness of children younger than 12 years to participate in the study
Exclusion criteria
Exclusion criteria: - 17 year of age - use of Temozolomide or other chemotherapeutic drug - language barrier (parents or caregivers) - current treatment with steroids of treated within 3 weeks before start of the study - fatty acid disorders (like MCAD) - Hypertrigyceridemia (> 10mmol/l) - kidney stones - diabetes mellitus - pancreatitis - gastro intestinal problems like persistent diarrhoea - parents unable to handel dietary instructions NB: use of tube feeding is NOT an exclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| determination of safety and feasibility of the ketogenic diet in children with recurrent of progressive pontine glioma during study period of 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| stabilisation of neurological functioning patient survival | — |
Countries
Netherlands
Outcome results
None listed