Evaluation of the citrulline generation test (CGT) using intravenous administration of glutamine-alanine in ICU patients with multiple organ dysfunction.

Evaluation of the citrulline generation test (CGT) using intravenous administration of glutamine-alanine in ICU patients with multiple organ dysfunction. - Small bowel function in MODS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33173

Enrollment

Registered

2009-03-24

Start date

2009-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

multiorgaan falen na sepsis, trauma, pancreatitis, shock, etc multiple organ dysfunction syndrome multiple organ failure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: age between 18-80 years;informed consent;The presence of multiple organ dysfunction syndrome (MODS), defined as more than 2 failing organs, irrespective of the aetiology (page 5, protocol)

Exclusion criteria

Exclusion criteria: *Documented causes of small bowel malabsorption possibly interfering with intestinal absorptive function, e.g. coeliac disease, Crohn*s disease of the small bowel, exocrine pancreatic insufficiency, radiation enteritis or short bowel syndrome. *Small intestinal resections and/or extensive colonic resection (> 2/3). *Liver cirrhosis Child-Pugh B or C, acute liver failure or renal failure requiring artificial support (e.g. CVVH). *Urea cycle defects/citrullinaemia. *Pregnancy (no long-term data are available on the effects of Dipeptiven* during pregnancy or lactation). *Use of (par)enteral medium chain triglycerides (MCT) or glutamine/citrulline supplements.

Design outcomes

Primary

Measure	Time frame
results of CGT testing: baseline citrulline levels, citrulline generation (AUC) after stimulation with intravenous glutamine sugar absorption testing to define intestinal permeability assessment of intestinal absorption using bombcalorimetry	—

Secondary

Measure	Time frame
comparison of primary parameters with nutritional indices and prognostic outcome parameters	—

Countries

Netherlands

Outcome results