Variability in bleeding phenotype in patients with hemophilia A.

Variability in bleeding phenotype in patients with hemophilia A. - Variability in phenotype in hemophilia A

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33172

Enrollment

Registered

2010-01-04

Start date

2010-12-22

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coagulation disorder hemophilia A

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Severe hemophilia A Most mild or most severe phenotype. Age 18 years or older

Exclusion criteria

Exclusion criteria: Alcohol abuse. Use of medication which is known to influence platelet function Drug use (cannabis).

Design outcomes

Primary

Measure	Time frame
To investigate the association of platelet responsiveness (EC50 of CRP stimulation, iloprost inhibition, and ADP stimulation) with clinical phenotype in patients with severe hemophilia A.	—

Secondary

Measure	Time frame
To investigate the association of systemic platelet activation with clinical phenotype in patients with severe hemophilia A.	—

Countries

Netherlands

Outcome results