Investigation of the skin barrier properties of healthy subjects and atopic eczema patients

Investigation of the skin barrier properties of healthy subjects and atopic eczema patients - Skin barrier properties of healthy subjects and AE patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33171

Enrollment

Registered

2009-11-06

Start date

2010-03-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic dermatitis neurodermitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age between 18-40 years - Caucasian

Exclusion criteria

Exclusion criteria: - Aged under 18 or over 40; - Non-Caucasian; - Abundant hair presence on the upper ventral forearms; - Unnatural abnormalities on one of their ventral forearms (e.g. skin lesions, tattoos); - Subjects using any systemic drug therapy (e.g. cholesterol-lowering drugs, insulin related drugs, steroids) or subjects who received phototherapy in the past 2 years.;Additional exclusion criteria for healthy subjects - No chronically inflammatory disease; - No dermatological disorders or a history of dermatological disorders; - No use of dermatological products (e.g. creams) on a daily basis.

Design outcomes

Primary

Measure	Time frame
- Lipid organization by Infrared and Raman spectroscopy and electron diffraction; - Lipid composition by LC/MS.	—

Secondary

Measure	Time frame
- Transepidermal water loss (TEWL) - Water levels in the SC - NMF level in the SC	—

Countries

Netherlands

Outcome results