lymfopenie t.g.v. stamceltransplantatie lymphopenia
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: a. healthy, 20-30 years of age, HIV-negative b. healthy, 60 years or older, HIV-negative c. healthy, 18 years or older, complete thymus removed at young age because of heart surgery d. stem cell transplantation patiënt, 18 years or older, treated for hematological malignancies with an autologous HSCT, HIV-negative e. 18 years or older, untreated HIV-1-infection
Exclusion criteria
Exclusion criteria: a, b, c. do not suffer from immunological disorders and show no obvious symptoms of infections d. do not suffer from graft-versus-host-disease or severe (viral) infections e. do not receive antiviral therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main parameter of the study is the amount of deuterium (label) that the different leukocyte populations have incorporated in their DNA by cell division at a given time. For this purpose blood withdrawals are done both in the period during which participants drink 2H2O (uplabelling phase), and in the period after stopping with 2H2O intake (delabelling phase). Data obtained during uplabelling and delabelling phases can be interpreted by mathematical models that describe the dynamics of leukocyte populations. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed