Genetic background of Löfgren's Syndrome

Genetic background of Löfgren's Syndrome - LOFGREN

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33149

Enrollment

300

Registered

2009-04-16

Start date

2009-06-22

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute sarcoidosis Besnier-Boeck-Schaumann

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients diagnosed with Löfgren*s syndrome. - Löfgren*s syndrome is defined according to the latest ATS/ERS/WASOG statement as presenting the clinical features, i.e.: o Acute symptoms like fever o Bilateral hilar lymphadenopath on chest radiograph o Erythema nodosum and/or joint symptoms (marked periarticular inflammation or arthritis of the ankles) - Capability of giving informed consent

Exclusion criteria

Exclusion criteria: patients with: - Non-Löfgren sarcoidosis - Other granulomatous diseases

Design outcomes

Primary

Measure	Time frame
To investigate an association between the genetics and the susceptibility to Löfgren*s syndrome, DNA analysis will be done. For the genomic DNA extraction whole blood will be used. When a genetic predisposition is found, in vitro proliferation and cytokine production assays will be performed to investigate the functional effects.	—

Secondary

Measure	Time frame
Our secondary objective is to investigate the blood analysis, pulmonary function tests and radioscopic examination to distinguish between the patients having a good and a bad prognosis. And to find parameters that could have predicting value about the course and outcome of the disease.	—

Countries

Netherlands

Outcome results