Correlation between prednisolone in saliva and (unbound) prednisolone in blood in healthy adults

Correlation between prednisolone in saliva and (unbound) prednisolone in blood in healthy adults - PSBHA

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33121

Enrollment

Registered

2009-07-02

Start date

2009-11-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gezonde vrijwilligers Pharmacokinetics in healthy volunteers

Interventions

A single oral administration of an 80 mg prednisolone capsule.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age 18-65 years

Exclusion criteria

Exclusion criteria: Use of medication that can influence pharmacokinetics of prednisolone * hormonal contraceptives * rifampicin * phenytoin * barbiturates * ketoconazole ;Conditons that can infuence pharmacokitetics of prednisolone * Pregnancy * Liver of renal dysfunction * Renal transplantation * Hyperthyroidism * Crohn's disease * Cushing's disease or syndrome * Chronic lesions of the oral mucosa or tongue Diabetes Mellitus

Design outcomes

Primary

Measure	Time frame
Prednisolone concentrations (nmol/L): a. serum (total) b. serum (unbound/free) c. saliva Measurements: before ingestion of 80 mg prednisolone and 1, 2, 3, 4, 5 and 6 hours after ingestion.	—

Secondary

Measure	Time frame
serum albumine level (g/L) serum corticosteroid binding globulin (CBG) level (mg/L)	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)