diabetic nephropathy kidney-pancreas transplantation
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 -70 years 2. Female or male 3. Kidney-pancreas transplantation 4. Patients must be able to adhere to the study visit schedule and protocol requirements. 5. Patients must be able to give informed consent and the consent must be obtained prior to any study procedure.
Exclusion criteria
Exclusion criteria: 1. Patients with evidence of active infection or abcesses 2. Patients suffering from hepatic failure. 3. Patients suffering from an active autoimmune disease 4. Patients with epilepsy 5. Malignancy (including lymphoproliferative disease) within the past 2-5 years (except for squamous or basal cell carcinoma of the skin that has been treated with no evidence of recurrence). 6. Subjects who currently have an active opportunistic infection (e.g., herpes zoster [shingles], cytomegalovirus (CMV), Pneumocystis carinii (PCP), aspergillosis, histoplasmosis, or mycobacteria other than TB)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non- invasive assessment of microvascular structure in diabetic nephropathy patients before and after kidney-pancreas transplantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Does kidney-pancreas transplantation improve microvascular damage assessed by OPS? 2.Does OPS correlate with serum and urine markers for fibrosis and endothelial dysfunction in these patients? | — |
Countries
Netherlands
Outcome results
None listed