Drugsgebruik brain damage Neurotoxicity
Conditions
Interventions
Non-invasive 3.0 Tesla MR imaging of cerebral hemodynamics following an
intravenous bolus injection of citalopram (7,5 mg). For the PWI studies in
addition two intravenous bolus injections of a cont
Gadovist) will be administered. For the SPECT studies a registrated and
well-validated radioligand ([123I]*-CIT) will be administered intravenously.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Male -Between 18 and 30 years of age
Exclusion criteria
Exclusion criteria: -Serious general medical condition or one that could interfere in the interpretation of results -use of (5-HT) medication within the last 2 weeks -excessive consumption of alcohol (>21 units/ week), caffeine (greater than eight cups of coffee per day) or cigarettes (greater than ten cigarettes per day). -Contraindications for MRI (e.g. osteosynthetic material, pacemaker, artificial cardiac valves), claustrophobia -Contraindications for contrast agent: renal disease (serum creatinine * 110 mmol/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BOLD: % change in BOLD SI from baseline (ROI) PWI: % change in ratio from baseline (ROI: rCBV/white matter rCBV) ASL: % change in CBF from baseline (ROI CBF/100 mg tissue) SPECT: SERT ratio (striatal ROI binding/binding in cerebellum) Visual analogue rating scale (VAS) | — |
Countries
Netherlands
Outcome results
None listed