The effect of two dosing regimens cefotaxime on the presence of potential pathogenic micro-organisms in airways.

The effect of two dosing regimens cefotaxime on the presence of potential pathogenic micro-organisms in airways. - The effect of two dosing regimens cefotaxime in the context of SDD.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33091

Enrollment

104

Registered

2009-10-28

Start date

2010-02-15

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

in potential harmful bacteria potential pathogenic microorganisms

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All patients expected to be intubated for more than 24 hours. All non-intubated patiënts who are expected to receive enteral tube feeding for more than 48 hours.

Exclusion criteria

Exclusion criteria: Pneumonia at admission on the ICU Expected death within 48 hours Immunocompromised patients Pregnancy Antibiotic therapy within the last 48 hours before admission at the ICU No informed consent within 24 hours after admission at the ICU Cephalosporin allergy ICU admission in the previous 30 days Age below 18 years

Design outcomes

Primary

Measure	Time frame
The primary study parameter is airway colonisation by potential pathogenic microorganisms after four days of selective decontamination of the digestive tract.	—

Secondary

Measure	Time frame
Secondary study parameters are length of stay on the ICU, length of stay in the hospital, ICU mortality, hospital mortality, duration of mechanical ventilation and pneumonia during ICU admission following the criteria of the Centers for Disease Control.	—

Countries

Netherlands

Outcome results