disturbed vasodilation Microvascular dysfunction
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Caucasian* 2. age 18-55 years 3. 20 35 * because capillaries are not visible in the nailfold in a pigmented skin
Exclusion criteria
Exclusion criteria: 1. cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 2. pulmonary disease 3. diabetes mellitus (FPG > 7.8 mmol/l) 4. liver dysfunction (ASAT, ALAT and/or alkaline phosphatase >3 times the upper limit of normal) 5. renal failure 6. smoking 7. alcohol use > 4 U/day 8. use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NSAIDs, ciclosporin A, rifampicin) 9. pregnancy 10. insufficient knowledge of the Dutch language. 11. known previous allergic reaction to ultrasound contrast-agent (e.g. Sonovue)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. percentage change in muscle microvascular blood volume as measured by CEUS. 2. percentage change in number of capillaries as measured by nailfold capillaroscopy. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. muscle microvascular flow velocity (percentage change) 2. muscle microvascular blood flow (percentage change) 3. time to peak flow 4. muscle microvascular flow distribution 5. whole body glucose uptake 6. total forearm blood flow (percentage change) 7. blood pressure | — |
Countries
Netherlands
Outcome results
None listed