Post-hartchirurgie patienten fluid challenge volume responsiveness
Conditions
Interventions
During surgery, pericardial and pleural drains are routinely placed. For the
patients that participate in the present study, these drains will be
accompanied by small catheters for pressure measurem
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Elective open heart surgery
Exclusion criteria
Exclusion criteria: Significant cardiac arrhythmias, including atrial fibrillation Hemodynamically instability, as defined by a variation in heart rate, blood pressure and cardiac output of more than 10% during the 15-min period before starting the protocol. Recent myocardial infarction ( 50ug/l)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is a new dynamic parameter that is indexed to tidal volume to predict volume responsiveness and decrease the number of unnecessary (and potential harmful) fluid challenges on the ICU. | — |
Secondary
| Measure | Time frame |
|---|---|
| The second study endpoint is a physiological relational model that describes the distribution of breathing pressures during controlled and supported mechanical ventilation at 2 different thorax compliances. The third endpoint is a reliable method for the prediction of volume responsiveness with the combination of the Nexfin (noninvasive CO technique) and the passive leg raising test. | — |
Countries
Netherlands
Outcome results
None listed