inflammatoire respons op intravasale toediening van endotoxine infection inflammation
Conditions
Interventions
All subjects will recieve an intravenous bolus administration of endotoxin.
Starting 1 hour before and ending 9 hours after endotoxin administration, the
subjects will recieve either enriched entera
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male >= 18 years old and
Exclusion criteria
Exclusion criteria: medication (e.g. NSAID's, antibiotics, gastrointestinal motility agents, corticosteroids) smoking in the past year history, signs or symptoms of cardiovascular disease (family)history of cerebrovascular disease previous vagal collaps hypertension hypotension renal impairment liver enzyme abnormalities positive hepatitis serology positive HIV test allergy to milk and/or soy protein Any gastro-intestinal disease or disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma concentration TNF-alpha | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory parameters (CRP, leukocytes, IL-6, IL-8, IL-10) intestinal epithelial damage (I-FABP) endothelial activation (adhesion molecules) Vagal activity (heart rate variability) Kidney damage (GSTA1-1, GSTP1-1, NGAL, IL-18, KIM-1) Splanchnic perfusion (gastric tonometry) Clinical symptoms (e.g. HR, RR, body temperature) | — |
Countries
Netherlands
Outcome results
None listed