Assessment of acute chest pain by computed tomography angiography

Assessment of acute chest pain by computed tomography angiography - Acute chest pain by CT angiography

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON33025

Enrollment

150

Registered

2009-06-25

Start date

2009-07-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute coronary syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients, >40 years, with acute chest pain, suspected for an acute coronary syndrom

Exclusion criteria

Exclusion criteria: When immediate coronary angiography is indicated (ST-elevatie myocardial infarction, hemodynamic instability, significant arrhythmia). When an acute coronary syndrome is very unlikely based on presentation, demographics, risk factors and initial test results. CT contrast medium allergy, impaired renal function, pregnancy.

Design outcomes

Primary

Measure	Time frame
1) Accuracy to detect/exclude ACS based on: coronary obstruction, plaque, myocardial enhancement, alternative diagnoses. 2) Evaluate the (potential) consequenes of a CT-based approach in terms of: admissions, catheterizations, time, expenses. 3) Ability of CT to detect vulnerable plaque (on OCT), based on: plaque density, size, calcification, eccentricity, remodeling.	—

Secondary

Measure	Time frame
1) Identify patient subcategories in whom CT angiography had most (or least) relevant diagnostic value, based on: demographics, clinical presentation, initial test results: ECG, biomarkers, CT-specific characteristics: heart rate, BMI. 2) Correlation between CT angiography and catheter angiography for the detection of coronary stenosis. 3) Correlation between CT angiography and exercise testing for the detection of significant coronary artery disease. 4) Respective diagnostic contributions of CT angiography, plaque imaging and myocardial enhancement.	—

Measure

Time frame

1) Identify patient subcategories in whom CT angiography had most (or least) relevant diagnostic value, based on: demographics, clinical presentation, initial test results: ECG, biomarkers, CT-specific characteristics: heart rate, BMI. 2) Correlation between CT angiography and catheter angiography for the detection of coronary stenosis. 3) Correlation between CT angiography and exercise testing for the detection of significant coronary artery disease. 4) Respective diagnostic contributions of CT angiography, plaque imaging and myocardial enhancement.

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Countries

Netherlands

Outcome results