overweight (25 < BMI < 30) bulky Corpulence
Conditions
Interventions
The study consists of a exercise protocol of 30 min. This exercise protocol is
executed twice, once under sea level conditions and once under high altitude
simulation (2000 m). For each individual t
Sponsors
HAN University (Hogeschool van Arnhem en Nijmegen)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Women Self reported healthy 20 - 40 years 25
Exclusion criteria
Exclusion criteria: Extreme sensitive to hypoxia (oxygen saturation 5.8 mmol/L and/or glucosuria) • Following weight-reduction programme or medically prescribed diet • Weight change > 2 kg during the last 2 months • Medication that may influence energy metabolism, weight or food intake • Gastrointestinal disorders (blood in stool, constipation and diarrhoea) • History of medical or surgical events that may affect the study outcome • Blood donation in the last month before the study or during the study • Abnormal ECG or impaired lung function
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| As parameter of energy expenditure whole body oxygen consumption is measured via indirect calorimetry (ventilated hood). A work load of 85 Watt on a bike ergometer (the maximum in this study) requires at sea level an energy expenditure of 20.4 kJ/min. We expect that the same work load under high altitude simulation requires an energy expenditure of 28.6 kJ/min, an increase of about 40%. In other words a work load of 85 Watt under high altitude simulation is associated with an energy expenditure for which under sea level conditions a work load of 115 Watt has to be applied. | — |
Secondary
| Measure | Time frame |
|---|---|
| The CO2 production of the subjects is also measured via the ventilated hood system. In combination with the oxygen consumption the Respiratory Quotient (RQ = CO2/O2) can be determined. Changes in RQ are indicative for for changes in substrate use. During the exercise protocols at regular time intervals 10 ul blood samples are taken from the middle finger to detect changes in glucose and lactate levels in peripheral blood. During the exercise protocols the lactate level should be higher compared to rest and may increase slightly. The physiological condition of the subjects is continuously monitored via oxygen saturation of the blood (SpO2), the heart rate (HR) and a RPE (Rate of Perceived Exertion) questionaire. The protcol is stopped when the subject wants to do so and when the pre-determined endpoint values are reached; SpO2 80% HRmax. | — |
Countries
Netherlands
Outcome results
None listed