HIV-1 evolution after transmission - A cohort study to identify evolution of recently transmitted HIV-1

HIV-1 evolution after transmission - A cohort study to identify evolution of recently transmitted HIV-1 - HIV-1 evolution after transmission

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32993

Enrollment

Registered

2009-02-09

Start date

2009-02-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

human immunodeficiency virus type1

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * HIV-1 infected partner(s) who are assumed to be the source of HIV-1 transmission (donor) of patients who present with primary HIV-1 infection at the *Primo-SHM* study (recipient) in the AMC (MEC 03/059). * At least 18 years of age

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
* Sequence of the viral genome that is present in the HIV-1 donor as close as possible to the time of HIV-1 transmission. * Virus diversity (quasispecies) in the donor-recipient pairs half a year after HIV-1 transmission. * HLA type of donor-recipient pairs, availability of replication competent (pseudo)viruses from donor and recipient.	—

Secondary

Measure	Time frame
The relation between viral sequence dynamics and: * The HLA type of donor and recipient * The autologous neutralization profile * Host CTL responses * Viral fitness	—

Countries

Netherlands

Outcome results