Vessel wall atheroma
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Main inclusion criteria for stroke patients and TIA patients: • 18 years or older • Male or female • Ready for MRI scanning within 1 week after onset of ischemic symptoms;Additional inclusion criteria for stroke patients: • Ischemic symptoms conform PACI/TACI (Partial/Total Anterior Circulation Infarct) • CT acute stroke imaging protocol: area of ischemia of the cerebral anterior perfusion territory based either on anatomical CT images or on CT perfusion images;Additional inclusion criteria for TIA patients: • Transient ischemic symptoms (
Exclusion criteria
Exclusion criteria: • Stroke patients with either a hyperdense vessel sign on CT or occlusion of an artery of the anterior cerebral circulation on CT angiography, but not both or neither • Patients with a known cardiac cause of stroke • Patients with a stroke secondary to surgical / interventional procedures • Allergic reaction to gadolinium • Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our main study parameter is the presence or absence of intracranial atherosclerosis in one (or more) arteries of the anterior cerebral circulation in the aforementioned groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are signal characteristics of the intracranial vessel wall atheroma on multiple MRI-sequences and two different magnetic field strengths, combined with histology as golden standard if applicable. Our (secondary) outcome will be cognitive functioning of the subject, in association with possible microvascular damage. | — |
Countries
Netherlands
Outcome results
None listed