Lesional epilepsy: the effects of surgical intervention on ictal onset zone and permissive neural networks

Lesional epilepsy: the effects of surgical intervention on ictal onset zone and permissive neural networks - LESION Lesional epilepsy and neural networks

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32984

Enrollment

Registered

2009-07-21

Start date

2010-02-24

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy seizures

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for pharmacoresistant epilepsy patients are (1) adult (>18 years) patients who (2) undergo resective surgical treatment at the VUmc regarding the Dutch Collaborative Epilepsy Surgery Program and (3) have given written informed consent. ;For brain tumour patients with epilepsy, inclusion criteria are (1) adult (* 18 years) patients who (2) undergo resective surgical treatment of the tumour with epilepsy surgery techniques at the VUmc, (3) are suffering from epilepsy which was not pre-existent to the lesion and (4) have given written informed consent.

Exclusion criteria

Exclusion criteria: Exclusion criteria are (1) psychiatric disease or symptoms, (2) insufficient mastery of the Dutch language, (3) inability to communicate adequately.

Design outcomes

Primary

Measure	Time frame
The main study parameters are ECoG and MEG measures assessing functional connectivity and neuronal brain networks (clustering coefficient and path length), as well as the clinical measures of seizure frequency, epilepsy burden and cognition.	—

Secondary

Measure	Time frame
This includes the MRI scans.	—

Countries

Netherlands

Outcome results