Cognition in classic galactosemia: What happens to the developing brain?

Cognition in classic galactosemia: What happens to the developing brain? - Cognition and the developing brain in galactosemia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32979

Enrollment

Registered

2009-07-17

Start date

2010-01-13

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Classic Galactosemia

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: A diagnosis of classic galactosemia as assessed by GALT enzyme activity assay or GALT-gene mutation analysis (information obtained from treating physician) Age between 10 and 18 years old

Exclusion criteria

Exclusion criteria: Any other disorder or disease that could affect cognitive functioning independently of classic galactosemia (an exception is made for the diagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD), because this disorder is common in this group)

Design outcomes

Primary

Measure	Time frame
The main parameters are 1) the performance on the speech-related behavioural paradigms (four paradigms, each focusing on one aspect of speech processing or production) and; 2) the event-related potentials (ERPs) extracted from the EEG recorded during the behavioural tasks.	—

Secondary

Measure	Time frame
The secundary parameter is the performance on the neuropsychological testbattery (i.e. a composition of tests focusing on the major cognitive domains: memory, attention, speech and language, visuo-motor skills).	—

Countries

Netherlands

Outcome results