Diabetes type 2 Insulin resistance
Conditions
Interventions
Children:
The subjects will be studied in two occasions, 24 h apart while receiving TPN
at two different amounts of protein intake (standard vs. higher protein intake)
with a Hyperinsulinemic Euglyc
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: Hyperglycemic critically ill
Exclusion criteria
Exclusion criteria: metabolic disease (eg Diabetes Mellitus)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Children: Whole body protein balance at baseline and during a HEC with standard and high protein intake in critically ill children. Neonates: Whole body protein balance at baseline and during a HEC with standard protein intake in critically ill term and preterm neonates. | — |
Secondary
| Measure | Time frame |
|---|---|
| Children: - Insulin resistance with standard and high protein intake in critically ill children - Glucose metabolism at baseline and during a HEC with standard and high protein intake in critically ill children. - Lipid metabolism at baseline and during a HEC with standard and high protein intake in critically ill children. - To determine the fractional (FSR) and absolute (ASR) synthesis rate of albumin and C-reactive protein at baseline and during HEC with standard and high protein intake in critically ill septic children. Neonates: - Insulin resistance in critically ill term and preterm neonates. - Glucose metabolism at baseline and during a HEC in critically ill term and preterm neonates. - Gluconeogenesis and glycogenesis at baseline and during a HEC in critically ill term and preterm neonates. - Compare plasma glucose values with continuous subcutaneous glucometer values at baseline and during a HEC in critically ill term and preterm neonates. | — |
Countries
Netherlands
Outcome results
None listed