In vivo evaluation of esophageal mucosal permeability in patients with non erosive reflux disease

In vivo evaluation of esophageal mucosal permeability in patients with non erosive reflux disease - permeability and NERD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON32964

Enrollment

Registered

2009-09-14

Start date

2009-06-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastro-esophageal reflux disease (GERD) heartburn

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: - Age 18 * 75 years - Written informed consent Healthy volunteers: - Age 18 * 75 years - Written informed consent

Exclusion criteria

Exclusion criteria: Patients: - Surgery of the GE-tract other than appendectomy - Use of PPI, or other medication influencing gastric or GI motility - patients unable to undergo endoscopy - Allergy to fluoresceine, midazolam, buscopan - Renal insuffiency Healthy volunteers: - Surgery of the GE-tract other than appendectomy - Gastro-intestinal complaints, including typical GERD complaints - Medication influencing gastric motility or GI motility - Allergy to fluoresceine, midazolam, buscopan - Renal insuffiency

Design outcomes

Primary

Measure	Time frame
Primary outcome parameter is the permeability as measusered by fluorescein diffusion. It is measured by the identifiable layers of epithelium after certain times of spraying.	—

Secondary

Measure	Time frame
Secondary outcome variables: - permeability, as measured in vitro in ussing chambers - expression of tight junction proteins - occurence of dilated intercellular spaces	—

Countries

Netherlands

Outcome results