The role of the left and right frontal hemisphere on mood and behaviour: A transcranial direct current stimulation study

The role of the left and right frontal hemisphere on mood and behaviour: A transcranial direct current stimulation study - tDCS and frontal asymmetry

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON32944

Enrollment

Registered

2009-10-14

Start date

2009-11-10

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

not applicable

Interventions

MANIPULATION Transcranial direct current stimulation (tDCS) will be delivered by a battery-driven constant DC current stimulator (Eldith DC Stimulator (CE 0118), Ilmenau) using a pair of electrodes

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Non-smoking, right-handed, 18-35 years

Exclusion criteria

Exclusion criteria: Skin disease, metal in cranium, use of psychotropic drugs, including cannabis, XTC, amphetamines and cocaine, epilepsy or family history of epilepsy, history of closed-head injury, history of head surgery, history of neurological or psychiatric disorders, medication use (i.e., benzodiazepines, antidepressants and neuroleptica), medication pump, brain infarction, heart disease, cardiac pacemaker, pregnancy or electronic hearing devices.

Design outcomes

Primary

Measure	Time frame
1. Background electroencephalogram: To monitor changes in electric activity an background electroencephalogram (EEG) will be recorded from 32 scalp locations according to the International 10-20 EEG System using Ag-AgCl-tipped electrodes (sampling rate: 256 Hz) before and immediately after tDCS (page 11-12 of the protocol). 2. Cerebral physiology: Transcranial magnetic stimulation (TMS) will be used to examine brain asymmetry by measuring cortical excitability of the left and right hemisphere, and left-to-right and right-to-left inter-hemispheric connectivity (page 12-13 of the protocol). 3. Behavior: Selective attention for emotional faces will be indexed using an emotional Stroop task comparing colour-naming latencies for neutral, angry, fearful and happy faces (page 13 of the protocol). 4. Mood will be monitored using the 20-item Profile of Mood States questionnaire (Shacham, 1983) (page 14 of the protocol).	—

Measure

Time frame

1. Background electroencephalogram: To monitor changes in electric activity an background electroencephalogram (EEG) will be recorded from 32 scalp locations according to the International 10-20 EEG System using Ag-AgCl-tipped electrodes (sampling rate: 256 Hz) before and immediately after tDCS (page 11-12 of the protocol). 2. Cerebral physiology: Transcranial magnetic stimulation (TMS) will be used to examine brain asymmetry by measuring cortical excitability of the left and right hemisphere, and left-to-right and right-to-left inter-hemispheric connectivity (page 12-13 of the protocol). 3. Behavior: Selective attention for emotional faces will be indexed using an emotional Stroop task comparing colour-naming latencies for neutral, angry, fearful and happy faces (page 13 of the protocol). 4. Mood will be monitored using the 20-item Profile of Mood States questionnaire (Shacham, 1983) (page 14 of the protocol).

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)